Human helminthiasis, known as worm infections, is any macroparasitic disease affecting humans, in which a part of the body is invaded by a lot of worms, known as helminths. They are broadly classified into flukes, tapeworms, and roundworms. Soil-transmitted helminthiasis and schistosomiasis are the most important, being included into the neglected tropical diseases. Helminthiasis has been found to result in poor birth outcome, less cognitive development, lower school and work performance, lower socioeconomic development, and poverty. Soil-transmitted helminthiases are responsible for parasitic infections in as much as a quarter of the human population worldwide. This group of infective diseases has been targeted under the joint action of the world's leading pharmaceutical companies and local governments, trying to achieve their eradication.
This book aims to provide fundamental knowledge and information for research in molecular systematics on parasitic helminths (nematode, trematode, cestode). The shreds of evidence of molecular systematics studies will be compiled and discussed in terms of the utilities and pitfalls of the genetic marker used for various purposes, which have been implemented for molecular systematics of parasitic nematodes, cestodes, and trematodes. Moreover, this book will also provide the procedure for research on molecular systematics and DNA taxonomy as the guideline to explore parasitic helminths. Finally, the further perspectives of utilizing genetic markers for molecular studies on parasitic helminths will be addressed in the context of applications from the laboratory to fieldwork such as DNA barcoding and environmental DNA metabarcoding of parasitic helminths. The book will benefit postgraduate students and researchers requiring the detailed knowledge of molecular systematics, as well as researchers desiring a guideline to select genetic markers and analyze DNA sequences to make phylogenetic inferences
Dr. Paul Giacomin is a co-founder of Paragen Bio. Dr. Siracusa is the founder and president of Nemagen Discoveries. The other Topic Editors declare no competing interests with regard to the Research Topic subject.
Publisher: Karger Medical and Scientific Publishers
Just as the magnitude of the growth and developmental problems attributable to human helminthiasis are being fully realized, we are able for the first time to describe defined immune responses giving rise to the pathological lesions seen. On the basis of the different sets of cytokines produced by CD4+ T cells, these responses can be classified according to the Th1/Th2/Th0 paradigm. Deleterious inflammatory responses to metazoan parasites appear to be consistently associated with a highly polarized Th2 cytokine profile. Thus, host-parasite models involving specific enteric and tissue helminths have provided seminal data on immunoregulatory and immunopathogenetic responses that are more broadly generalizable to the entire Th1/Th2 paradigm. The first three articles in this volume present an overview of recent advances in the understanding of the induction of IgE, eosinophilic, and cytokine regulatory responses to helminthic infection. Subsequent articles comprehensively review immunopathogenetic aspects of schistosomiasis, hookworm infection, echinococcosis, lymphatic filariasis, onchocerciasis, toxocariasis, and cysticercosis, and, at the same time, emphasize key directions and priorities. Conclusions from animal models of infection are set in the context of human disease wherever possible. For all immunologists with an interest in cytokine biology and for those interested in the biology of tropical infectious diseases this volume is essential reading.
Designed for associate-degree MLT/CLT programs and baccalaureate MT/CLS programs, this textbook presents the essentials of clinical microbiology. It provides balanced coverage of specific groups of microorganisms and the work-up of clinical specimens by organ system, and also discusses the role of the microbiology laboratory in regard to emerging infections, healthcare epidemiology, and bioterrorism. Clinical case studies and self-assessment questions show how to incorporate the information into everyday practice. More than 400 illustrations and visual information displays enhance the text. Essentials boxes, chapter outlines, key terms, summaries, and other study aids help students retain information. A bound-in CD-ROM includes additional review questions, case studies, and Web links.
Designed to introduce senior undergraduates and graduate students in public health and nursing to the study of infectious disease, Foundations of Infectious Disease: A Public Health Perspective places the study of infectious diseases squarely into its social, historical, and scientific context to demonstrate how it applies to the public and community health setting. Beginning with an introductory chapter that surveys how infectious diseases have impacted human societies over the centuries, this broad descriptive text moves on to examine epidemiological concepts related to infectious disease, from outbreak and epidemic investigations, to study design infectious disease transmission and prevention. Subsequentially, it delves into infectious disease topics of concern to today's public and community health professionals: sexually transmitted infections, foodborne infections, healthcare-acquired infections, and neglected tropical diseases.
In spite of the availability of modern broad-spectrum anthelmintic drugs, the prevention and control of helminth zoonoses remain a challenge to human and veterinary parasitologists and to physicians and veterina rians working on the field. Although the life cycles of most helminths of zoonotic importance are well known, there are still major gaps in our knowledge especially in the fields of epidemiology, diagnosis and treat ment The International Colloquium on Helminth Zoonoses held at the Institute of Tropical Medicine, Antwerp, 11-12 December 1986, laid emphasis on more recent advances made in the control and epidemiology of these zoonotic diseases. The disease complexes echinococcosis/hydatidosis, taeniasis/cysticercosis and the larva migrans-syndrome were dealth with in considerable detail. In the first chapter the phenomenon of strain variation in Echinococcus spp. is examined in the light of newer findings. The progress made in recent years towards a more specific diagnosis and drug targeting in hydatidosis is reported. In the second chapter recent advances in immunisation and treatment of cysticercosis are dealt with. The possibili ty of the existence of strain differences in Taenia saginata is also dis cussed. The third chapter is devoted to trematode zoonoses with particular reference to the situation in South-east Asia, Senegal (schistosomiasis) and Liberia (paragonimiasis). In the last chapter the larva migrans syndrome is treated in detail with special attention to its etiology and and diagnosis. Reports on lesser known nematode zoonoses like mammomono gamosis and oesophagostomiasis are included.
Publisher: American Society for Microbiology Press
The most authoritative, comprehensive reference in the field. • Sets the standard for state-of-the-science laboratory practice. • A collaborative effort of 22 editors and more than 260 authors from around the world, all experienced researchers and practitioners in medical and diagnostic microbiology. • Includes 149 chapters of the latest research findings, infectious agents, methods, practices, and safety guidelines. • Indispensable to clinical microbiologists, laboratory technologists, and infectious disease specialists in hospitals, clinics, reference laboratories, and more
Infectious Diseases: Selected Entries from the Encyclopedia of Sustainability Science and Technology presents authoritative, peer-reviewed contributions from leading experts on a wide range of major infectious diseases of global importance. Infectious diseases account for more than 17 million deaths each year worldwide. While modern medicine and technology have diminished the threat of many of these pathogens in high-income countries, the ever present threats of re-emerging infections, population mobility, natural disasters, and pathogen genetic variability are but some of the reasons for the dynamic threat of this broad category of risks to human health. An indispensable resource for students and scientists, the volume also covers some of the new technologies currently under development for infectious disease prevention, treatment, and eradication. The greater part of the infectious disease burden remains in the tropics, where low and middle-income countries lack the resources, infrastructure, and health systems to mount or sustain control efforts. Many contributions describe the efforts of the scientific research community and international donor agencies to achieve the integrated goals of vigilant surveillance, improved and cost-effective diagnostics, and treatment for sustainable disease control.
We acknowledge the initiation and support of this Research Topic by the InternationalUnion of Immunological Societies (IUIS). We hereby state publicly that the IUIS hashad no editorial input in articles included in this Research Topic, thus ensuring that allaspects of this Research Topic are evaluated objectively, unbiased by any specific policyor opinion of the IUIS.